Structure-based design, synthesis, and biological evaluation of novel piperine–resveratrol hybrids as antiproliferative agents targeting SIRT-2

A series of novel piperine–resveratrol hybrids 5a–h was designed, synthesized, and structurally elucidated by IR, and (1)H, (13)C, and (19)F NMR. Antiproliferative activities of 5a–h were evaluated by NCI against sixty cancer cell lines. Compound 5b, possessing resveratrol pharmacophoric phenolic mo...

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Detalles Bibliográficos
Autores principales: Tantawy, Ahmed H., Meng, Xiang-Gao, Marzouk, Adel A., Fouad, Ali, Abdelazeem, Ahmed H., Youssif, Bahaa G. M., Jiang, Hong, Wang, Man-Qun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9037111/
https://www.ncbi.nlm.nih.gov/pubmed/35478872
http://dx.doi.org/10.1039/d1ra04061h

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9037111/
https://www.ncbi.nlm.nih.gov/pubmed/35478872
http://dx.doi.org/10.1039/d1ra04061h

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