Ligand-based design and synthesis of N'-Benzylidene-3,4-dimethoxybenzohydrazide derivatives as potential antimicrobial agents; evaluation by in vitro, in vivo, and in silico approaches with SAR studies

Herein, a series of N'-benzylidene-3,4-dimethoxybenzohydrazide derivatives were designed and synthesised to target the multidrug efflux pump (MATE). The antibacterial activities were screened against S. aureus, Acinetobacter, S. typhi, E. coli, and P. aeruginosa, whereas their antifungal activi...

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Detalles Bibliográficos
Autores principales: Ezz Eldin, Rogy R., Saleh, Marwa A., Alotaibi, Mohammad Hayal, Alsuair, Reem K., Alzahrani, Yahya A., Alshehri, Feras A., Mohamed, Amany F., Hafez, Shaimaa M., Althoqapy, Azza Ali, Khirala, Seham K., Amin, Mona M., A. F, Yousuf, AbdElwahab, Azza H., Alesawy, Mohamed S., Elmaaty, Ayman Abo, Al-Karmalawy, Ahmed A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9037180/
https://www.ncbi.nlm.nih.gov/pubmed/35430934
http://dx.doi.org/10.1080/14756366.2022.2063282

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9037180/
https://www.ncbi.nlm.nih.gov/pubmed/35430934
http://dx.doi.org/10.1080/14756366.2022.2063282

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