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Ligand-based design and synthesis of N'-Benzylidene-3,4-dimethoxybenzohydrazide derivatives as potential antimicrobial agents; evaluation by in vitro, in vivo, and in silico approaches with SAR studies
Herein, a series of N'-benzylidene-3,4-dimethoxybenzohydrazide derivatives were designed and synthesised to target the multidrug efflux pump (MATE). The antibacterial activities were screened against S. aureus, Acinetobacter, S. typhi, E. coli, and P. aeruginosa, whereas their antifungal activi...
Autores principales: | Ezz Eldin, Rogy R., Saleh, Marwa A., Alotaibi, Mohammad Hayal, Alsuair, Reem K., Alzahrani, Yahya A., Alshehri, Feras A., Mohamed, Amany F., Hafez, Shaimaa M., Althoqapy, Azza Ali, Khirala, Seham K., Amin, Mona M., A. F, Yousuf, AbdElwahab, Azza H., Alesawy, Mohamed S., Elmaaty, Ayman Abo, Al-Karmalawy, Ahmed A. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9037180/ https://www.ncbi.nlm.nih.gov/pubmed/35430934 http://dx.doi.org/10.1080/14756366.2022.2063282 |
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