Cargando…
Interactions of 2,6-substituted purines with purine nucleoside phosphorylase from Helicobacter pylori in solution and in the crystal, and the effects of these compounds on cell cultures of this bacterium
Helicobacter pylori represents a global health threat with around 50% of the world population infected. Due to the increasing number of antibiotic-resistant strains, new strategies for eradication of H. pylori are needed. In this study, we suggest purine nucleoside phosphorylase (PNP) as a possible...
Autores principales: | Narczyk, Marta, Wojtyś, Marta Ilona, Leščić Ašler, Ivana, Žinić, Biserka, Luić, Marija, Jagusztyn-Krynicka, Elżbieta Katarzyna, Štefanić, Zoran, Bzowska, Agnieszka |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9037209/ https://www.ncbi.nlm.nih.gov/pubmed/35437103 http://dx.doi.org/10.1080/14756366.2022.2061965 |
Ejemplares similares
-
A comprehensive method for determining cellular uptake of purine nucleoside phosphorylase and adenylosuccinate synthetase inhibitors by H. pylori
por: Wojtyś, Marta Ilona, et al.
Publicado: (2021) -
Crystallographic snapshots of ligand binding to hexameric purine nucleoside phosphorylase and kinetic studies give insight into the mechanism of catalysis
por: Štefanić, Zoran, et al.
Publicado: (2018) -
In the quest for new targets for pathogen eradication: the adenylosuccinate synthetase from the bacterium Helicobacter pylori
por: Bubić, Ante, et al.
Publicado: (2018) -
Single tryptophan Y160W mutant of homooligomeric E. coli purine nucleoside phosphorylase implies that dimers forming the hexamer are functionally not equivalent
por: Narczyk, Marta, et al.
Publicado: (2021) -
Purine nucleoside phosphorylase is associated with centrioles and basal bodies
Publicado: (1981)