Cargando…

Design, synthesis, and cytotoxic activities of isaindigotone derivatives as potential anti-gastric cancer agents

A series of novel derivatives of isaindigotone, which comes from the root of isaits indinatca Fort, were synthesised (Compound 1–26). Four human gastrointestinal cancer cells (HCT116, PANC-1, SMMC-7721, and AGS) were employed to evaluate the anti-proliferative activity. Among them, Compound 6 displa...

Descripción completa

Detalles Bibliográficos
Autores principales:	Du, Kangjia, Ma, Wantong, Yang, Chengjie, Zhou, Zhongkun, Hu, Shujian, Tian, Yanan, Zhang, Hao, Ma, Yunhao, Jiang, Xinrong, Zhu, Hongmei, Liu, Huanxiang, Chen, Peng, Liu, Yingqian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2022
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9037217/ https://www.ncbi.nlm.nih.gov/pubmed/35450499 http://dx.doi.org/10.1080/14756366.2022.2065672

Ejemplares similares

A Novel Isaindigotone Derivative Displays Better Anti-Proliferation Activities and Induces Apoptosis in Gastric Cancer Cells
por: Du, Kangjia, et al.
Publicado: (2022)

Design, Synthesis and Biological Evaluation of Neocryptolepine Derivatives as Potential Anti-Gastric Cancer Agents
por: Ma, Yunhao, et al.
Publicado: (2022)

Biological Evaluation of 8-Methoxy-2,5-dimethyl-5H-indolo[2,3-b] Quinoline as a Potential Antitumor Agent via PI3K/AKT/mTOR Signaling
por: Ma, Yunhao, et al.
Publicado: (2023)

Human Gut Microbiome-Based Knowledgebase as a Biomarker Screening Tool to Improve the Predicted Probability for Colorectal Cancer
por: Zhou, Zhongkun, et al.
Publicado: (2020)

Vanillin Derivatives Reverse Fusobacterium nucleatum-Induced Proliferation and Migration of Colorectal Cancer Through E-Cadherin/β-Catenin Pathway
por: Zhou, Zhongkun, et al.
Publicado: (2022)

Anti-Gastric Cancer Activity of the Cell-free Culture Supernatant of Serofluid Dish and Lactiplantibacillus plantarum YT013
por: Zhang, Rentao, et al.
Publicado: (2022)

Rhizoma Gastrodiae Water Extract Modulates the Gut Microbiota and Pathological Changes of P-Tau(Thr231) to Protect Against Cognitive Impairment in Mice
por: Zhao, Wenbin, et al.
Publicado: (2022)

Synthesis, molecular docking, and cytotoxicity of quinazolinone and dihydroquinazolinone derivatives as cytotoxic agents
por: Taayoshi, Fahimeh, et al.
Publicado: (2022)

Synthesis of 4-Hydroxyquinolines as Potential Cytotoxic Agents †
por: Csuvik, Oszkár, et al.
Publicado: (2022)

Synthesis and Cytotoxicity Evaluation of 13-n-Alkyl Berberine and Palmatine Analogues as Anticancer Agents
por: Zhang, Lei, et al.
Publicado: (2012)

Design, synthesis and structure–activity relationships of mangostin analogs as cytotoxic agents
por: Chi, Xiao-Qian, et al.
Publicado: (2018)

Synthesis and In Vitro Cytotoxic Activity of Novel Chalcone-Like Agents
por: Letafat, Bahram, et al.
Publicado: (2013)

Facile synthesis of chiral phenylselenides as novel antioxidants and cytotoxic agents
por: Laskowska, Anna, et al.
Publicado: (2023)

Design and Synthesis of Molecular Hybrids of Sophora Alkaloids and Cinnamic Acids as Potential Antitumor Agents
por: Shang, Hai, et al.
Publicado: (2020)

Design, synthesis and cytotoxic evaluation of novel betulonic acid-diazine derivatives as potential antitumor agents
por: Shu, Yisong, et al.
Publicado: (2022)

Synthesis of hydroxycinnamic acid derivatives as mitochondria-targeted antioxidants and cytotoxic agents
por: Li, Jiyu, et al.
Publicado: (2017)

Synthesis and cytotoxic evaluation of novel quinazolinone derivatives as potential anticancer agents
por: Poorirani, Safoora, et al.
Publicado: (2018)

Design, Synthesis and Biological Evaluation of Novel Piperazinone Derivatives as Cytotoxic Agents
por: Ghasemi, Saeed, et al.
Publicado: (2020)

Synthesis of some novel dibromo-2-arylquinazolinone derivatives as cytotoxic agents
por: Faghih, Zeinab, et al.
Publicado: (2019)

Synthesis and bioactivity evaluation of pachymic acid derivatives as potential cytotoxic agents
por: Wang, Hezhen, et al.
Publicado: (2022)

Machine learning-based predictive model for the differential diagnosis of ≤ 5 cm gastric stromal tumor and gastric schwannoma based on CT images
por: Chen, Guoxian, et al.
Publicado: (2023)

Synthesis and biological evaluation of novel 7-hydroxy-4-phenylchromen-2-one–linked to triazole moieties as potent cytotoxic agents
por: Liu, Chuan-Feng, et al.
Publicado: (2017)

Synthesis, Cytotoxicity, DNA Binding and Apoptosis of Rhein-Phosphonate Derivatives as Antitumor Agents
por: Ye, Man-Yi, et al.
Publicado: (2013)

Synthesis and Cytotoxic Evaluation of Monocarbonyl Analogs of Curcumin as Potential Anti‐Tumor Agents
por: Pan, Zheer, et al.
Publicado: (2016)

Nicotinamide-based diamides derivatives as potential cytotoxic agents: synthesis and biological evaluation
por: Peng, Min, et al.
Publicado: (2017)

Ruthenium-based PACT agents based on bisquinoline chelates: synthesis, photochemistry, and cytotoxicity
por: Busemann, Anja, et al.
Publicado: (2021)

The Synthesis and Evaluation of Amidoximes as Cytotoxic Agents on Model Bacterial E. coli Strains
por: Samsonowicz-Górski, Jan, et al.
Publicado: (2021)

Design and Synthesis of 4-O-Podophyllotoxin Sulfamate Derivatives as Potential Cytotoxic Agents
por: Bader, Ammar, et al.
Publicado: (2021)

Design, synthesis and evaluation of novel tetrahydropyridothienopyrimidin-ureas as cytotoxic and anti-angiogenic agents
por: Motahari, Rasoul, et al.
Publicado: (2022)

Design and Synthesis of Scopoletin Sulfonate Derivatives as Potential Insecticidal Agents
por: Liu, Congmin, et al.
Publicado: (2023)

WADDAICA: A webserver for aiding protein drug design by artificial intelligence and classical algorithm
por: Bai, Qifeng, et al.
Publicado: (2021)

Design, synthesis and biological evaluation of novel benzodioxole derivatives as COX inhibitors and cytotoxic agents
por: Hawash, Mohammed, et al.
Publicado: (2020)

The Synthesis and Evaluation of Aminocoumarin Peptidomimetics as Cytotoxic Agents on Model Bacterial E. coli Strains
por: Kowalczyk, Paweł, et al.
Publicado: (2021)

Cytotoxicity of Xenogeneic Pericardium Preserved by Epoxy Cross-Linking Agents
por: Bondarenko, N.A., et al.
Publicado: (2021)

Synthesis and Cytotoxic Evaluation of Sanjoseolide and Representative Analogues
por: Tian, Tian, et al.
Publicado: (2020)

Synthesis and characterisation of (Z)-styrylbenzene derivatives as potential selective anticancer agents
por: Xin, Ya-Bing, et al.
Publicado: (2018)

Total synthesis, structure revision and cytotoxic activity of Sch 53825 and its derivatives
por: Xu, Leichuan, et al.
Publicado: (2022)

The synergistic effects of Apatinib combined with cytotoxic chemotherapeutic agents on gastric cancer cells and in a fluorescence imaging gastric cancer xenograft model
por: Feng, Jiuhuan, et al.
Publicado: (2018)

2-(4-Fluorophenyl)-N-phenylacetamide Derivatives as Anticancer Agents: Synthesis and In-vitro Cytotoxicity Evaluation
por: Aliabadi, Alireza, et al.
Publicado: (2013)

Synthesis, Docking and Biological Activities of Novel Hybrids Celecoxib and Anthraquinone Analogs as Potent Cytotoxic Agents
por: Almutairi, Maha S., et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_qpjtqmjnru18lnilkrbg0b0t3n