Downregulation of IGFBP5 contributes to replicative senescence via ERK2 activation in mouse embryonic fibroblasts

Insulin-like growth factor (IGF)-binding proteins (IGFBPs) are secretory proteins that regulate IGF signaling. In this study, we investigated the role of IGFBP5 in replicative senescence in embryonic mouse fibroblasts (MEFs). During passages according to the 3T3 method, MEFs underwent senescence aft...

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Detalles Bibliográficos
Autores principales: Nojima, Iyori, Hosoda, Ryusuke, Toda, Yuki, Saito, Yoshiki, Ueda, Naohiro, Horimoto, Kouhei, Iwahara, Naotoshi, Horio, Yoshiyuki, Kuno, Atsushi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9037271/
https://www.ncbi.nlm.nih.gov/pubmed/35378512
http://dx.doi.org/10.18632/aging.203999

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9037271/
https://www.ncbi.nlm.nih.gov/pubmed/35378512
http://dx.doi.org/10.18632/aging.203999

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