Cytosolic Ca(2+)-dependent Ca(2+) release activity primarily determines the ER Ca(2+) level in cells expressing the CPVT-linked mutant RYR2

Type 2 ryanodine receptor (RYR2) is a cardiac Ca(2+) release channel in the ER. Mutations in RYR2 are linked to catecholaminergic polymorphic ventricular tachycardia (CPVT). CPVT is associated with enhanced spontaneous Ca(2+) release, which tends to occur when [Ca(2+)](ER) reaches a threshold. Mutat...

Descripción completa

Detalles Bibliográficos
Autores principales: Kurebayashi, Nagomi, Murayama, Takashi, Ota, Ryosaku, Suzuki, Junji, Kanemaru, Kazunori, Kobayashi, Takuya, Ohno, Seiko, Horie, Minoru, Iino, Masamitsu, Yamashita, Fumiyoshi, Sakurai, Takashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9037340/
https://www.ncbi.nlm.nih.gov/pubmed/35446340
http://dx.doi.org/10.1085/jgp.202112869

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9037340/
https://www.ncbi.nlm.nih.gov/pubmed/35446340
http://dx.doi.org/10.1085/jgp.202112869

Ejemplares similares