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Cytosolic Ca(2+)-dependent Ca(2+) release activity primarily determines the ER Ca(2+) level in cells expressing the CPVT-linked mutant RYR2

Type 2 ryanodine receptor (RYR2) is a cardiac Ca(2+) release channel in the ER. Mutations in RYR2 are linked to catecholaminergic polymorphic ventricular tachycardia (CPVT). CPVT is associated with enhanced spontaneous Ca(2+) release, which tends to occur when [Ca(2+)](ER) reaches a threshold. Mutat...

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Detalles Bibliográficos
Autores principales:	Kurebayashi, Nagomi, Murayama, Takashi, Ota, Ryosaku, Suzuki, Junji, Kanemaru, Kazunori, Kobayashi, Takuya, Ohno, Seiko, Horie, Minoru, Iino, Masamitsu, Yamashita, Fumiyoshi, Sakurai, Takashi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Rockefeller University Press 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9037340/ https://www.ncbi.nlm.nih.gov/pubmed/35446340 http://dx.doi.org/10.1085/jgp.202112869

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