A diversity outbred F1 mouse model identifies host-intrinsic genetic regulators of response to immune checkpoint inhibitors

Immune checkpoint inhibitors (ICI) have improved outcomes for a variety of malignancies; however, many patients fail to benefit. While tumor-intrinsic mechanisms are likely involved in therapy resistance, it is unclear to what extent host genetic background influences response. To investigate this,...

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Detalles Bibliográficos
Autores principales: Hackett, Justin B., Glassbrook, James E., Muñiz, Maria C., Bross, Madeline, Fielder, Abigail, Dyson, Gregory, Movahhedin, Nasrin, McCasland, Jennifer, McCarthy-Leo, Claire, Gibson, Heather M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9037414/
https://www.ncbi.nlm.nih.gov/pubmed/35481286
http://dx.doi.org/10.1080/2162402X.2022.2064958

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9037414/
https://www.ncbi.nlm.nih.gov/pubmed/35481286
http://dx.doi.org/10.1080/2162402X.2022.2064958

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