Exendin-4 stimulates autophagy in pancreatic β-cells via the RAPGEF/EPAC-Ca(2+)-PPP3/calcineurin-TFEB axis

Macroautophagy/autophagy is critical for the regulation of pancreatic β-cell mass and its deregulation has been implicated in the pathogenesis of type 2 diabetes (T2D). We have previously shown that treatment of pancreatic β-cells with the GLP1R (glucagon like peptide 1 receptor) agonist exendin-4 s...

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Detalles Bibliográficos
Autores principales: Zummo, Francesco P, Krishnanda, Stanislaus I, Georgiou, Merilin, O’Harte, Finbarr PM, Parthsarathy, Vadivel, Cullen, Kirsty S, Honkanen-Scott, Minna, Shaw, James AM, Lovat, Penny E, Arden, Catherine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9037459/
https://www.ncbi.nlm.nih.gov/pubmed/34338148
http://dx.doi.org/10.1080/15548627.2021.1956123

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9037459/
https://www.ncbi.nlm.nih.gov/pubmed/34338148
http://dx.doi.org/10.1080/15548627.2021.1956123

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