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Ubiquitylation of unphosphorylated c-myc by novel E3 ligase SCF(Fbxl8)
Overexpression of c-myc via increased transcription or decreased protein degradation is common to many cancer etiologies. c-myc protein degradation is mediated by ubiquitin-dependent degradation, and this ubiquitylation is regulated by several E3 ligases. The primary regulator is Fbxw7, which binds...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Taylor & Francis
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9037475/ https://www.ncbi.nlm.nih.gov/pubmed/35438057 http://dx.doi.org/10.1080/15384047.2022.2061279 |