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TRIM44 links the UPS to SQSTM1/p62-dependent aggrephagy and removing misfolded proteins

Until recently, the ubiquitin-proteasome system (UPS) and macroautophagy/autophagy were considered to be two independent systems that target proteins for degradation by proteasomes or via lysosomes, respectively. Here, we report that TRIM44 (tripartite motif containing 44) is a novel link that conne...

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Detalles Bibliográficos
Autores principales: Lyu, Lin, Chen, Zheng, McCarty, Nami
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9037492/
https://www.ncbi.nlm.nih.gov/pubmed/34382902
http://dx.doi.org/10.1080/15548627.2021.1956105