Palladium-catalyzed dehydrogenative C–H cyclization for isoindolinone synthesis

In this paper Pd-catalyzed intramolecular dehydrogenative C(sp(3))–H amidation for the synthesis of isoindolinones is described. This method features the use of a Pd/C catalyst and the addition of a stoichiometric amount of oxidant is not necessary. A mechanistic study suggested the possible formati...

Descripción completa

Detalles Bibliográficos
Autores principales: Abe, Masahiro, Ueta, Kaho, Tanaka, Saki, Kimachi, Tetsutaro, Inamoto, Kiyofumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9037686/
https://www.ncbi.nlm.nih.gov/pubmed/35479970
http://dx.doi.org/10.1039/d1ra04661f
_version_ 1784693771158421504
author Abe, Masahiro
Ueta, Kaho
Tanaka, Saki
Kimachi, Tetsutaro
Inamoto, Kiyofumi
author_facet Abe, Masahiro
Ueta, Kaho
Tanaka, Saki
Kimachi, Tetsutaro
Inamoto, Kiyofumi
author_sort Abe, Masahiro
collection PubMed
description In this paper Pd-catalyzed intramolecular dehydrogenative C(sp(3))–H amidation for the synthesis of isoindolinones is described. This method features the use of a Pd/C catalyst and the addition of a stoichiometric amount of oxidant is not necessary. A mechanistic study suggested the possible formation of H(2) gas during the reaction.
format Online
Article
Text
id pubmed-9037686
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher The Royal Society of Chemistry
record_format MEDLINE/PubMed
spelling pubmed-90376862022-04-26 Palladium-catalyzed dehydrogenative C–H cyclization for isoindolinone synthesis Abe, Masahiro Ueta, Kaho Tanaka, Saki Kimachi, Tetsutaro Inamoto, Kiyofumi RSC Adv Chemistry In this paper Pd-catalyzed intramolecular dehydrogenative C(sp(3))–H amidation for the synthesis of isoindolinones is described. This method features the use of a Pd/C catalyst and the addition of a stoichiometric amount of oxidant is not necessary. A mechanistic study suggested the possible formation of H(2) gas during the reaction. The Royal Society of Chemistry 2021-08-08 /pmc/articles/PMC9037686/ /pubmed/35479970 http://dx.doi.org/10.1039/d1ra04661f Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/
spellingShingle Chemistry
Abe, Masahiro
Ueta, Kaho
Tanaka, Saki
Kimachi, Tetsutaro
Inamoto, Kiyofumi
Palladium-catalyzed dehydrogenative C–H cyclization for isoindolinone synthesis
title Palladium-catalyzed dehydrogenative C–H cyclization for isoindolinone synthesis
title_full Palladium-catalyzed dehydrogenative C–H cyclization for isoindolinone synthesis
title_fullStr Palladium-catalyzed dehydrogenative C–H cyclization for isoindolinone synthesis
title_full_unstemmed Palladium-catalyzed dehydrogenative C–H cyclization for isoindolinone synthesis
title_short Palladium-catalyzed dehydrogenative C–H cyclization for isoindolinone synthesis
title_sort palladium-catalyzed dehydrogenative c–h cyclization for isoindolinone synthesis
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9037686/
https://www.ncbi.nlm.nih.gov/pubmed/35479970
http://dx.doi.org/10.1039/d1ra04661f
work_keys_str_mv AT abemasahiro palladiumcatalyzeddehydrogenativechcyclizationforisoindolinonesynthesis
AT uetakaho palladiumcatalyzeddehydrogenativechcyclizationforisoindolinonesynthesis
AT tanakasaki palladiumcatalyzeddehydrogenativechcyclizationforisoindolinonesynthesis
AT kimachitetsutaro palladiumcatalyzeddehydrogenativechcyclizationforisoindolinonesynthesis
AT inamotokiyofumi palladiumcatalyzeddehydrogenativechcyclizationforisoindolinonesynthesis

Ejemplares similares