Design, synthesis, biological assessment and in silico ADME prediction of new 2-(4-(methylsulfonyl) phenyl) benzimidazoles as selective cyclooxygenase-2 inhibitors

A novel series of benzimidazole derivatives wherein 4-(methylsulfonyl) phenyl pharmacophore attached via its C-2 position was designed and synthesized. These compounds were evaluated in vitro as cyclooxygenase-1(COX-1)/cyclooxygenese-2(COX-2) inhibitors. Furthermore, the synthesized compounds were a...

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Detalles Bibliográficos
Autores principales: Badawy, Mohamed A. S., Abdelall, Eman K. A., EL-Nahass, EL-Shaymaa, Abdellatif, Khaled R. A., Abdel-Rahman, Hamdy M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9037807/
https://www.ncbi.nlm.nih.gov/pubmed/35480694
http://dx.doi.org/10.1039/d1ra04756f

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9037807/
https://www.ncbi.nlm.nih.gov/pubmed/35480694
http://dx.doi.org/10.1039/d1ra04756f

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