Convergent synthesis of 2-thioether-substituted (N)-methanocarba-adenosines as purine receptor agonists

A linear route has been used to prepare (N)-methanocarba-nucleoside derivatives, which serve as purine receptor ligands having a pre-established, receptor-preferred conformation. To introduce this rigid ribose substitute, a Mitsunobu reaction of a [3.1.0]bicyclohexane 5′-trityl intermediate 3 with a...

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Detalles Bibliográficos
Autores principales: Suresh, R. Rama, Poe, Russell B., Lin, Baorui, Lv, Kexin, Campbell, Ryan G., Gao, Zhan-Guo, Liston, Theodore E., Toti, Kiran S., Jacobson, Kenneth A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9037833/
https://www.ncbi.nlm.nih.gov/pubmed/35480676
http://dx.doi.org/10.1039/d1ra05096f

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9037833/
https://www.ncbi.nlm.nih.gov/pubmed/35480676
http://dx.doi.org/10.1039/d1ra05096f

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