Loop Extrusion Mediates Physiological IgH Locus Contraction For RAG Scanning

RAG endonuclease initiates IgH V(D)J recombination in pro-B cells by binding a J(H)-recombination signal sequence (RSS) within a recombination center (RC) and then linearly scanning upstream chromatin, presented by cohesin-mediated loop extrusion, for convergent D-RSSs(1,2). Utilization of convergen...

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Detalles Bibliográficos
Autores principales: Dai, Hai-Qiang, Hu, Hongli, Lou, Jiangman, Ye, Adam Yongxin, Ba, Zhaoqing, Zhang, Xuefei, Zhang, Yiwen, Zhao, Lijuan, Yoon, Hye Suk, Chapdelaine-Williams, Aimee M., Kyritsis, Nia, Chen, Huan, Johnson, Kerstin, Lin, Sherry, Conte, Andrea, Casellas, Rafael, Lee, Cheng-Sheng, Alt, Frederick W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9037962/
https://www.ncbi.nlm.nih.gov/pubmed/33442057
http://dx.doi.org/10.1038/s41586-020-03121-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9037962/
https://www.ncbi.nlm.nih.gov/pubmed/33442057
http://dx.doi.org/10.1038/s41586-020-03121-7

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