Copper(i)-catalyzed radical carboamination reaction of 8-aminoquinoline-oriented buteneamides with chloroform: synthesis of-β-lactams

A novel Cu(CH(3)CN)(4)PF(6)-catalyzed carboamination reaction of 8-aminoquinoline-oriented buteneamides with chloroform to afford 4-(2,2,2-trichloroethyl)-β-lactams is described. The reaction proceeded at 110 °C in air with di-t-butyl peroxide. Preliminary studies indicated that the reaction undergo...

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Detalles Bibliográficos
Autores principales: Gan, Zixu, Zhang, Ke, Shi, Peng, Zhao, Yingsheng, Zeng, Runsheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9037986/
https://www.ncbi.nlm.nih.gov/pubmed/35480755
http://dx.doi.org/10.1039/d1ra05233k
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author Gan, Zixu
Zhang, Ke
Shi, Peng
Zhao, Yingsheng
Zeng, Runsheng
author_facet Gan, Zixu
Zhang, Ke
Shi, Peng
Zhao, Yingsheng
Zeng, Runsheng
author_sort Gan, Zixu
collection PubMed
description A novel Cu(CH(3)CN)(4)PF(6)-catalyzed carboamination reaction of 8-aminoquinoline-oriented buteneamides with chloroform to afford 4-(2,2,2-trichloroethyl)-β-lactams is described. The reaction proceeded at 110 °C in air with di-t-butyl peroxide. Preliminary studies indicated that the reaction undergoes a free radical mechanism via a Cu(i)/Cu(ii)/Cu(iii) catalytic cycle.
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spelling pubmed-90379862022-04-26 Copper(i)-catalyzed radical carboamination reaction of 8-aminoquinoline-oriented buteneamides with chloroform: synthesis of-β-lactams Gan, Zixu Zhang, Ke Shi, Peng Zhao, Yingsheng Zeng, Runsheng RSC Adv Chemistry A novel Cu(CH(3)CN)(4)PF(6)-catalyzed carboamination reaction of 8-aminoquinoline-oriented buteneamides with chloroform to afford 4-(2,2,2-trichloroethyl)-β-lactams is described. The reaction proceeded at 110 °C in air with di-t-butyl peroxide. Preliminary studies indicated that the reaction undergoes a free radical mechanism via a Cu(i)/Cu(ii)/Cu(iii) catalytic cycle. The Royal Society of Chemistry 2021-08-19 /pmc/articles/PMC9037986/ /pubmed/35480755 http://dx.doi.org/10.1039/d1ra05233k Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Gan, Zixu
Zhang, Ke
Shi, Peng
Zhao, Yingsheng
Zeng, Runsheng
Copper(i)-catalyzed radical carboamination reaction of 8-aminoquinoline-oriented buteneamides with chloroform: synthesis of-β-lactams
title Copper(i)-catalyzed radical carboamination reaction of 8-aminoquinoline-oriented buteneamides with chloroform: synthesis of-β-lactams
title_full Copper(i)-catalyzed radical carboamination reaction of 8-aminoquinoline-oriented buteneamides with chloroform: synthesis of-β-lactams
title_fullStr Copper(i)-catalyzed radical carboamination reaction of 8-aminoquinoline-oriented buteneamides with chloroform: synthesis of-β-lactams
title_full_unstemmed Copper(i)-catalyzed radical carboamination reaction of 8-aminoquinoline-oriented buteneamides with chloroform: synthesis of-β-lactams
title_short Copper(i)-catalyzed radical carboamination reaction of 8-aminoquinoline-oriented buteneamides with chloroform: synthesis of-β-lactams
title_sort copper(i)-catalyzed radical carboamination reaction of 8-aminoquinoline-oriented buteneamides with chloroform: synthesis of-β-lactams
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9037986/
https://www.ncbi.nlm.nih.gov/pubmed/35480755
http://dx.doi.org/10.1039/d1ra05233k
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