Free spermidine evokes superoxide radicals that manifest toxicity

Spermidine and other polyamines alleviate oxidative stress, yet excess spermidine seems toxic to Escherichia coli unless it is neutralized by SpeG, an enzyme for the spermidine N-acetyl transferase function. Thus, wild-type E. coli can tolerate applied exogenous spermidine stress, but ΔspeG strain o...

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Detalles Bibliográficos
Autores principales: Kumar, Vineet, Mishra, Rajesh Kumar, Ghose, Debarghya, Kalita, Arunima, Dhiman, Pulkit, Prakash, Anand, Thakur, Nirja, Mitra, Gopa, Chaudhari, Vinod D, Arora, Amit, Dutta, Dipak
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9038194/
https://www.ncbi.nlm.nih.gov/pubmed/35416771
http://dx.doi.org/10.7554/eLife.77704

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9038194/
https://www.ncbi.nlm.nih.gov/pubmed/35416771
http://dx.doi.org/10.7554/eLife.77704

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