Development of De Novo Donor-specific HLA Antibodies and AMR in Renal Transplant Patients Depends on CYP3A5 Genotype

BACKGROUND. The single-nucleotide polymorphism CYP3A5 rs776746 is related to a reduction in the metabolizing activity of the CYP3A5 enzyme. People carrying at least one copy of the wild-type allele, defined as CYP3A5 expressers, exhibit higher clearance and lower trough concentrations of tacrolimus...

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Detalles Bibliográficos
Autores principales: Friebus-Kardash, Justa, Nela, Ejona, Möhlendick, Birte, Kribben, Andreas, Siffert, Winfried, Heinemann, Falko Markus, Eisenberger, Ute
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2021
Materias:
Original Clinical Science—General
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9038248/
https://www.ncbi.nlm.nih.gov/pubmed/34241984
http://dx.doi.org/10.1097/TP.0000000000003871

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9038248/
https://www.ncbi.nlm.nih.gov/pubmed/34241984
http://dx.doi.org/10.1097/TP.0000000000003871

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