A structural exposé of noncanonical molecular reactivity within the protein tyrosine phosphatase WPD loop

Structural snapshots of protein/ligand complexes are a prerequisite for gaining atomic level insight into enzymatic reaction mechanisms. An important group of enzymes has been deprived of this analytical privilege: members of the protein tyrosine phosphatase (PTP) superfamily with catalytic WPD-loop...

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Detalles Bibliográficos
Autores principales: Wang, Huanchen, Perera, Lalith, Jork, Nikolaus, Zong, Guangning, Riley, Andrew M., Potter, Barry V. L., Jessen, Henning J., Shears, Stephen B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9038691/
https://www.ncbi.nlm.nih.gov/pubmed/35468885
http://dx.doi.org/10.1038/s41467-022-29673-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9038691/
https://www.ncbi.nlm.nih.gov/pubmed/35468885
http://dx.doi.org/10.1038/s41467-022-29673-y

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