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A structural exposé of noncanonical molecular reactivity within the protein tyrosine phosphatase WPD loop
Structural snapshots of protein/ligand complexes are a prerequisite for gaining atomic level insight into enzymatic reaction mechanisms. An important group of enzymes has been deprived of this analytical privilege: members of the protein tyrosine phosphatase (PTP) superfamily with catalytic WPD-loop...
Autores principales: | Wang, Huanchen, Perera, Lalith, Jork, Nikolaus, Zong, Guangning, Riley, Andrew M., Potter, Barry V. L., Jessen, Henning J., Shears, Stephen B. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9038691/ https://www.ncbi.nlm.nih.gov/pubmed/35468885 http://dx.doi.org/10.1038/s41467-022-29673-y |
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