Triglyceride-Mimetic Prodrugs of Buprenorphine Enhance Oral Bioavailability via Promotion of Lymphatic Transport

Buprenorphine (BUP) is a potent opioid analgesic that is widely used for severe pain management and opioid replacement therapy. The oral bioavailability of BUP, however, is significantly limited by first-pass metabolism. Previous studies have shown that triglyceride (TG) mimetic prodrugs of the ster...

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Detalles Bibliográficos
Autores principales: Quach, Tim, Hu, Luojuan, Han, Sifei, Lim, Shea F., Senyschyn, Danielle, Yadav, Preeti, Trevaskis, Natalie L., Simpson, Jamie S., Porter, Christopher J. H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9039622/
https://www.ncbi.nlm.nih.gov/pubmed/35496278
http://dx.doi.org/10.3389/fphar.2022.879660

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9039622/
https://www.ncbi.nlm.nih.gov/pubmed/35496278
http://dx.doi.org/10.3389/fphar.2022.879660

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