Cargando…

Hmgcs2-mediated ketogenesis modulates high-fat diet-induced hepatosteatosis

OBJECTIVE: Aberrant ketogenesis is correlated with the degree of steatosis in non-alcoholic fatty liver disease (NAFLD) patients, and an inborn error of ketogenesis (mitochondrial HMG-CoA synthase deficiency) is commonly associated with the development of the fatty liver. Here we aimed to determine...

Descripción completa

Detalles Bibliográficos
Autores principales:	Asif, Shaza, Kim, Ri Youn, Fatica, Thet, Sim, Jordan, Zhao, Xiaoling, Oh, Yena, Denoncourt, Alix, Cheung, Angela C., Downey, Michael, Mulvihill, Erin E., Kim, Kyoung-Han
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9039870/ https://www.ncbi.nlm.nih.gov/pubmed/35421611 http://dx.doi.org/10.1016/j.molmet.2022.101494

Ejemplares similares

Recurrent loss of HMGCS2 shows that ketogenesis is not essential for the evolution of large mammalian brains
por: Jebb, David, et al.
Publicado: (2018)

Keratin 8 absence down-regulates colonocyte HMGCS2 and modulates colonic ketogenesis and energy metabolism
por: Helenius, Terhi O., et al.
Publicado: (2015)

Understanding Dietary Intervention-Mediated Epigenetic Modifications in Metabolic Diseases
por: Asif, Shaza, et al.
Publicado: (2020)

Dietary-Induced Ketogenesis: Adults Are Not Children
por: Porper, Keren, et al.
Publicado: (2021)

LOCALIZATION OF THE ENZYMES OF KETOGENESIS IN RAT LIVER MITOCHONDRIA
por: Chapman, M. John, et al.
Publicado: (1973)

Pathway Preferential Estrogens Prevent Hepatosteatosis Due to Ovariectomy and High-Fat Diets
por: Zuo, Qianying, et al.
Publicado: (2021)

Ceramides: Nutrient Signals that Drive Hepatosteatosis
por: Summers, Scott A.
Publicado: (2020)

Amphetamine-Like Analogues in Diabetes: Speeding towards Ketogenesis
por: Branis, Natalia M., et al.
Publicado: (2015)

Emerging Role of Hepatic Ketogenesis in Fatty Liver Disease
por: Mooli, Raja Gopal Reddy, et al.
Publicado: (2022)

Ketogenesis impact on liver metabolism revealed by proteomics of lysine β-hydroxybutyrylation
por: Koronowski, Kevin B., et al.
Publicado: (2021)

Mevalonate Pathway Enzyme HMGCS1 Contributes to Gastric Cancer Progression
por: Wang, I-Han, et al.
Publicado: (2020)

Impaired ketogenesis is associated with metabolic-associated fatty liver disease in subjects with type 2 diabetes
por: Lee, Sejeong, et al.
Publicado: (2023)

Ddp1 Cooperates with Ppx1 to Counter a Stress Response Initiated by Nonvacuolar Polyphosphate
por: McCarthy, Liam, et al.
Publicado: (2022)

A medium-chain fatty acid analogue prevents hepatosteatosis and decreases inflammatory lipid metabolites in a murine model of parenteral nutrition-induced hepatosteatosis
por: Cho, Bennet S., et al.
Publicado: (2023)

PTPRO-mediated autophagy prevents hepatosteatosis and tumorigenesis
por: Zhang, Wenjie, et al.
Publicado: (2015)

Hepatosteatosis from Lysosomal Acid Lipase Deficiency
por: Zandanell, Stephan, et al.
Publicado: (2018)

Role of hepatosteatosis in the prognosis of COVID 19 disease
por: Çoraplı, Mahmut, et al.
Publicado: (2021)

Sodium glucose transporter 2 (SGLT2) inhibition and ketogenesis
por: Kalra, Sanjay, et al.
Publicado: (2015)

Mammalian autophagy is essential for hepatic and renal ketogenesis during starvation
por: Takagi, Ayano, et al.
Publicado: (2016)

Hepatic Ketogenesis Induced by Middle Cerebral Artery Occlusion in Mice
por: Koch, Konrad, et al.
Publicado: (2017)

Impaired ketogenesis ties metabolism to T cell dysfunction in COVID-19
por: Karagiannis, Fotios, et al.
Publicado: (2022)

High Fat Diet Upregulates Fatty Acid Oxidation and Ketogenesis via Intervention of PPAR- γ
por: Sikder, Kunal, et al.
Publicado: (2018)

Detection of Impaired Cognitive Function in Rat with Hepatosteatosis Model and Improving Effect of GLP-1 Analogs (Exenatide) on Cognitive Function in Hepatosteatosis
por: Erbaş, Oytun, et al.
Publicado: (2014)

OR09-2 Pathway Preferential Estrogens Prevent Hepatosteatosis Due to Ovariectomy and High-Fat Diets
por: Zuo, Qianying, et al.
Publicado: (2019)

Fermented Cordyceps militaris Extract Prevents Hepatosteatosis and Adipocyte Hypertrophy in High Fat Diet-Fed Mice
por: Tran, Nguyen Khoi Song, et al.
Publicado: (2019)

Exercise in mice ameliorates high-fat diet-induced nonalcoholic fatty liver disease by lowering HMGCS2
por: Qian, Xiaoli, et al.
Publicado: (2021)

Idi1 and Hmgcs2 Are Affected by Stretch in HL-1 Atrial Myocytes
por: Fang, Chih-Yuan, et al.
Publicado: (2018)

HMGCS2 Mediates Ketone Production and Regulates the Proliferation and Metastasis of Hepatocellular Carcinoma
por: Wang, Yuan-Hsi, et al.
Publicado: (2019)

Liver HMGCS2 is critical in the maintenance of liver lipid homeostasis during fasting
por: Zhou, Yunfeng, et al.
Publicado: (2022)

Flos Lonicera Combined with Metformin Ameliorates Hepatosteatosis and Glucose Intolerance in Association with Gut Microbiota Modulation
por: Shin, Na R., et al.
Publicado: (2017)

Nutrigenomics Therapy of Hepatisis C Virus Induced-hepatosteatosis
por: Liu, Qing, et al.
Publicado: (2010)

A FATal AP-1 dimer switch in hepatosteatosis
por: Bakiri, Latifa, et al.
Publicado: (2014)

NTCP deficiency in mice protects against obesity and hepatosteatosis
por: Donkers, Joanne M., et al.
Publicado: (2019)

Endocan: A Biomarker for Hepatosteatosis in Patients with Metabolic Syndrome
por: Erman, Hande, et al.
Publicado: (2020)

Late-Onset Lipid Storage Myopathy with Fatal Hepatosteatosis
por: Yavuz, Arda, et al.
Publicado: (2020)

Regulation of Ketogenic Enzyme HMGCS2 by Wnt/β-catenin/PPARγ Pathway in Intestinal Cells
por: Kim, Ji Tae, et al.
Publicado: (2019)

Impact of ketogenesis and strong ion difference on acid-base in our CICU
por: Clark, T, et al.
Publicado: (2012)

Roles and Regulation of Ketogenesis in Cultured Astroglia and Neurons Under Hypoxia and Hypoglycemia
por: Takahashi, Shinichi, et al.
Publicado: (2014)

LBSUN213 An Investigation Into The Effects Of Dapagliflozin On Ketogenesis In Type 1 Diabetes
por: Ghanim, Husam, et al.
Publicado: (2022)

Renal and Cardiovascular Metabolic Impact Caused by Ketogenesis of the SGLT2 Inhibitors
por: Vargas-Delgado, Ariana P., et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_dapj81oac375q2lv67o2sga7do