Heart failure in mice induces a dysfunction of the sinus node associated with reduced CaMKII signaling

Dysfunction of the sinoatrial node (SAN), the natural heart pacemaker, is common in heart failure (HF) patients. SAN spontaneous activity relies on various ion currents in the plasma membrane (voltage clock), but intracellular Ca(2+) ([Ca(2+)](i)) release via ryanodine receptor 2 (RYR2; Ca(2+) clock...

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Detalles Bibliográficos
Autores principales: Xue, Jian-Bin, Val-Blasco, Almudena, Davoodi, Moran, Gómez, Susana, Yaniv, Yael, Benitah, Jean-Pierre, Gómez, Ana María
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9040062/
https://www.ncbi.nlm.nih.gov/pubmed/35452507
http://dx.doi.org/10.1085/jgp.202112895

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9040062/
https://www.ncbi.nlm.nih.gov/pubmed/35452507
http://dx.doi.org/10.1085/jgp.202112895

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