Cargando…
Heart failure in mice induces a dysfunction of the sinus node associated with reduced CaMKII signaling
Dysfunction of the sinoatrial node (SAN), the natural heart pacemaker, is common in heart failure (HF) patients. SAN spontaneous activity relies on various ion currents in the plasma membrane (voltage clock), but intracellular Ca(2+) ([Ca(2+)](i)) release via ryanodine receptor 2 (RYR2; Ca(2+) clock...
| Autores principales: | , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Rockefeller University Press
2022
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9040062/ https://www.ncbi.nlm.nih.gov/pubmed/35452507 http://dx.doi.org/10.1085/jgp.202112895 |