Engineered Cas12a-Plus nuclease enables gene editing with enhanced activity and specificity

BACKGROUND: The CRISPR-Cas12a (formerly Cpf1) system is a versatile gene-editing tool with properties distinct from the broadly used Cas9 system. Features such as recognition of T-rich protospacer-adjacent motif (PAM) and generation of sticky breaks, as well as amenability for multiplex editing in a...

Descripción completa

Detalles Bibliográficos
Autores principales: Huang, Hongxin, Huang, Guanjie, Tan, Zhihong, Hu, Yongfei, Shan, Lin, Zhou, Jiajian, Zhang, Xin, Ma, Shufeng, Lv, Weiqi, Huang, Tao, Liu, Yuchen, Wang, Dong, Zhao, Xiaoyang, Lin, Ying, Rong, Zhili
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Methodology Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9040236/
https://www.ncbi.nlm.nih.gov/pubmed/35468792
http://dx.doi.org/10.1186/s12915-022-01296-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9040236/
https://www.ncbi.nlm.nih.gov/pubmed/35468792
http://dx.doi.org/10.1186/s12915-022-01296-1

Ejemplares similares