Loss of perivascular aquaporin-4 localization impairs glymphatic exchange and promotes amyloid β plaque formation in mice

BACKGROUND: Slowed clearance of amyloid β (Aβ) is believed to underlie the development of Aβ plaques that characterize Alzheimer’s disease (AD). Aβ is cleared in part by the glymphatic system, a brain-wide network of perivascular pathways that supports the exchange of cerebrospinal and brain interst...

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Detalles Bibliográficos
Autores principales: Simon, Matthew, Wang, Marie Xun, Ismail, Ozama, Braun, Molly, Schindler, Abigail G., Reemmer, Jesica, Wang, Zhongya, Haveliwala, Mariya A., O’Boyle, Ryan P., Han, Warren Y., Roese, Natalie, Grafe, Marjorie, Woltjer, Randall, Boison, Detlev, Iliff, Jeffrey J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9040291/
https://www.ncbi.nlm.nih.gov/pubmed/35473943
http://dx.doi.org/10.1186/s13195-022-00999-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9040291/
https://www.ncbi.nlm.nih.gov/pubmed/35473943
http://dx.doi.org/10.1186/s13195-022-00999-5

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