Metallation of sensitive fluoroarenes using a potassium TMP-zincate supported by a silyl(bis)amido ligand

Combining a bulky bis(amide) and a reactive one-coordinate TMP (2,2,6,6-tetramethylpiperidide) ligand, a new mixed K/Zn heteroleptic base has been developed for regioselective zincation of fluoroarenes. This special ligand set allows for trapping and structural authentication of the first intermedia...

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Autores principales: Mastropierro, Pasquale, Kennedy, Alan R., Hevia, Eva
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9040423/
https://www.ncbi.nlm.nih.gov/pubmed/35403647
http://dx.doi.org/10.1039/d2cc00979j
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author Mastropierro, Pasquale
Kennedy, Alan R.
Hevia, Eva
author_facet Mastropierro, Pasquale
Kennedy, Alan R.
Hevia, Eva
author_sort Mastropierro, Pasquale
collection PubMed
description Combining a bulky bis(amide) and a reactive one-coordinate TMP (2,2,6,6-tetramethylpiperidide) ligand, a new mixed K/Zn heteroleptic base has been developed for regioselective zincation of fluoroarenes. This special ligand set allows for trapping and structural authentication of the first intermediates of direct Zn–H exchange of fluoroarenes obtained via deprotonative metallation, providing mechanistic insights of the processes involved.
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spelling pubmed-90404232022-06-01 Metallation of sensitive fluoroarenes using a potassium TMP-zincate supported by a silyl(bis)amido ligand Mastropierro, Pasquale Kennedy, Alan R. Hevia, Eva Chem Commun (Camb) Chemistry Combining a bulky bis(amide) and a reactive one-coordinate TMP (2,2,6,6-tetramethylpiperidide) ligand, a new mixed K/Zn heteroleptic base has been developed for regioselective zincation of fluoroarenes. This special ligand set allows for trapping and structural authentication of the first intermediates of direct Zn–H exchange of fluoroarenes obtained via deprotonative metallation, providing mechanistic insights of the processes involved. The Royal Society of Chemistry 2022-03-09 /pmc/articles/PMC9040423/ /pubmed/35403647 http://dx.doi.org/10.1039/d2cc00979j Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Mastropierro, Pasquale
Kennedy, Alan R.
Hevia, Eva
Metallation of sensitive fluoroarenes using a potassium TMP-zincate supported by a silyl(bis)amido ligand
title Metallation of sensitive fluoroarenes using a potassium TMP-zincate supported by a silyl(bis)amido ligand
title_full Metallation of sensitive fluoroarenes using a potassium TMP-zincate supported by a silyl(bis)amido ligand
title_fullStr Metallation of sensitive fluoroarenes using a potassium TMP-zincate supported by a silyl(bis)amido ligand
title_full_unstemmed Metallation of sensitive fluoroarenes using a potassium TMP-zincate supported by a silyl(bis)amido ligand
title_short Metallation of sensitive fluoroarenes using a potassium TMP-zincate supported by a silyl(bis)amido ligand
title_sort metallation of sensitive fluoroarenes using a potassium tmp-zincate supported by a silyl(bis)amido ligand
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9040423/
https://www.ncbi.nlm.nih.gov/pubmed/35403647
http://dx.doi.org/10.1039/d2cc00979j
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