Interrogation of Essentiality in the Reconstructed Haemophilus influenzae Metabolic Network Identifies Lipid Metabolism Antimicrobial Targets: Preclinical Evaluation of a FabH β-Ketoacyl-ACP Synthase Inhibitor

Expediting drug discovery to fight antibacterial resistance requires holistic approaches at system levels. In this study, we focused on the human-adapted pathogen Haemophilus influenzae, and by constructing a high-quality genome-scale metabolic model, we rationally identified new metabolic drug targ...

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Detalles Bibliográficos
Autores principales: López-López, Nahikari, León, David San, de Castro, Sonia, Díez-Martínez, Roberto, Iglesias-Bexiga, Manuel, Camarasa, María José, Menéndez, Margarita, Nogales, Juan, Garmendia, Junkal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9040583/
https://www.ncbi.nlm.nih.gov/pubmed/35293791
http://dx.doi.org/10.1128/msystems.01459-21

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9040583/
https://www.ncbi.nlm.nih.gov/pubmed/35293791
http://dx.doi.org/10.1128/msystems.01459-21

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