Titration of C-5 Sterol Desaturase Activity Reveals Its Relationship to Candida albicans Virulence and Antifungal Susceptibility Is Dependent upon Host Immune Status

The azole antifungals inhibit sterol 14α-demethylase (S14DM), which depletes cellular ergosterol and promotes synthesis of the dysfunctional lipid 14α-methylergosta-8,24(28)-dien-3β,6α-diol, ultimately arresting growth. Mutations that inactivate sterol Δ(5,6)-desaturase (Erg3p), the enzyme that prod...

Descripción completa

Detalles Bibliográficos
Autores principales: Regan, Jessica, DeJarnette, Christian, Luna-Tapia, Arturo, Parker, Josie E., Reitler, Parker, Barnett, Stacey, Tucker, Katie M., Kelly, Steven L., Palmer, Glen E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9040724/
https://www.ncbi.nlm.nih.gov/pubmed/35380453
http://dx.doi.org/10.1128/mbio.00115-22

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9040724/
https://www.ncbi.nlm.nih.gov/pubmed/35380453
http://dx.doi.org/10.1128/mbio.00115-22

Ejemplares similares