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Simultaneous determination of Avanafil and Dapoxetine in human plasma using liquid chromatography/tandem mass spectrometry (LC-MS/MS) based on a protein precipitation technique

A rapid and selective LC-MS/MS method is described for the simultaneous assay of Avanafil and Dapoxetine in human plasma via a protein precipitation (PP) sample preparation technique. Tadalafil was chosen as the internal standard reaching good recovery and reproducibility while diminishing the effec...

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Detalles Bibliográficos
Autores principales: Abou-Omar, Mona N., Annadi, Abdelaziz M., El Zahar, Noha M., Youssef, Ahmed. O., Amin, Mohammed A., Attia, Mohamed S., Mohamed, Ekram H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9040755/
https://www.ncbi.nlm.nih.gov/pubmed/35479534
http://dx.doi.org/10.1039/d1ra05492a