Gonococcal Clinical Strains Bearing a Common gdhR Single Nucleotide Polymorphism That Results in Enhanced Expression of the Virulence Gene lctP Frequently Possess a mtrR Promoter Mutation That Decreases Antibiotic Susceptibility

GdhR is a transcriptional repressor of the virulence factor gene lctP, which encodes a unique l-lactate permease that has been linked to pathogenesis of Neisseria gonorrhoeae, and loss of gdhR can confer increased fitness of gonococci in a female mouse model of lower genital tract infection. In this...

Descripción completa

Detalles Bibliográficos
Autores principales: Ayala, Julio C., Schmerer, Matthew W., Kersh, Ellen N., Unemo, Magnus, Shafer, William M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9040798/
https://www.ncbi.nlm.nih.gov/pubmed/35258329
http://dx.doi.org/10.1128/mbio.00276-22

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9040798/
https://www.ncbi.nlm.nih.gov/pubmed/35258329
http://dx.doi.org/10.1128/mbio.00276-22

Ejemplares similares