A Single Amino Acid Switch in the Adenoviral DNA Binding Protein Abrogates Replication Center Formation and Productive Viral Infection

Adenoviruses are very efficient high-capacity vaccine vectors and are common gene delivery systems. Despite their extensive use in preclinical models and clinical trials over the past decades, adenoviral vectors still require optimization. To achieve that, more thorough characterizations of adenovir...

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Detalles Bibliográficos
Autores principales: Boddin, Jana, Ip, Wing-Hang, Wilkens, Britta, von Stromberg, Konstantin, Ching, Wilhelm, Koyuncu, Emre, Bertzbach, Luca D., Dobner, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9040859/
https://www.ncbi.nlm.nih.gov/pubmed/35254132
http://dx.doi.org/10.1128/mbio.00144-22

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9040859/
https://www.ncbi.nlm.nih.gov/pubmed/35254132
http://dx.doi.org/10.1128/mbio.00144-22

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