Resistance-Guided Mining of Bacterial Genotoxins Defines a Family of DNA Glycosylases

Unique DNA repair enzymes that provide self-resistance against therapeutically important, genotoxic natural products have been discovered in bacterial biosynthetic gene clusters (BGCs). Among these, the DNA glycosylase AlkZ is essential for azinomycin B production and belongs to the HTH_42 superfami...

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Detalles Bibliográficos
Autores principales: Bradley, Noah P., Wahl, Katherine L., Steenwyk, Jacob L., Rokas, Antonis, Eichman, Brandt F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9040887/
https://www.ncbi.nlm.nih.gov/pubmed/35311535
http://dx.doi.org/10.1128/mbio.03297-21

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9040887/
https://www.ncbi.nlm.nih.gov/pubmed/35311535
http://dx.doi.org/10.1128/mbio.03297-21

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