ZnCl(2)-promoted domino reaction of 2-hydroxybenzonitriles with ketones for synthesis of 1,3-benzoxazin-4-ones

A ZnCl(2)-promoted synthesis of 1,3-benzoxazin-4-one from 2-hydroxybenzonitriles and ketones was developed. This method displays facile access to a diverse range of substituted 1,3-benzoxazin-4-ones in good yields. This synthetic protocol has advantages: (i) easy availability of starting material; (...

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Detalles Bibliográficos
Autores principales: Su, Ziqi, Chai, Hongxin, Xu, Juan, Li, Jiarong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9040917/
https://www.ncbi.nlm.nih.gov/pubmed/35480257
http://dx.doi.org/10.1039/d1ra04194k
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author Su, Ziqi
Chai, Hongxin
Xu, Juan
Li, Jiarong
author_facet Su, Ziqi
Chai, Hongxin
Xu, Juan
Li, Jiarong
author_sort Su, Ziqi
collection PubMed
description A ZnCl(2)-promoted synthesis of 1,3-benzoxazin-4-one from 2-hydroxybenzonitriles and ketones was developed. This method displays facile access to a diverse range of substituted 1,3-benzoxazin-4-ones in good yields. This synthetic protocol has advantages: (i) easy availability of starting material; (ii) strong corrosive acid-free condition; (iii) high yield.
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spelling pubmed-90409172022-04-26 ZnCl(2)-promoted domino reaction of 2-hydroxybenzonitriles with ketones for synthesis of 1,3-benzoxazin-4-ones Su, Ziqi Chai, Hongxin Xu, Juan Li, Jiarong RSC Adv Chemistry A ZnCl(2)-promoted synthesis of 1,3-benzoxazin-4-one from 2-hydroxybenzonitriles and ketones was developed. This method displays facile access to a diverse range of substituted 1,3-benzoxazin-4-ones in good yields. This synthetic protocol has advantages: (i) easy availability of starting material; (ii) strong corrosive acid-free condition; (iii) high yield. The Royal Society of Chemistry 2021-09-06 /pmc/articles/PMC9040917/ /pubmed/35480257 http://dx.doi.org/10.1039/d1ra04194k Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Su, Ziqi
Chai, Hongxin
Xu, Juan
Li, Jiarong
ZnCl(2)-promoted domino reaction of 2-hydroxybenzonitriles with ketones for synthesis of 1,3-benzoxazin-4-ones
title ZnCl(2)-promoted domino reaction of 2-hydroxybenzonitriles with ketones for synthesis of 1,3-benzoxazin-4-ones
title_full ZnCl(2)-promoted domino reaction of 2-hydroxybenzonitriles with ketones for synthesis of 1,3-benzoxazin-4-ones
title_fullStr ZnCl(2)-promoted domino reaction of 2-hydroxybenzonitriles with ketones for synthesis of 1,3-benzoxazin-4-ones
title_full_unstemmed ZnCl(2)-promoted domino reaction of 2-hydroxybenzonitriles with ketones for synthesis of 1,3-benzoxazin-4-ones
title_short ZnCl(2)-promoted domino reaction of 2-hydroxybenzonitriles with ketones for synthesis of 1,3-benzoxazin-4-ones
title_sort zncl(2)-promoted domino reaction of 2-hydroxybenzonitriles with ketones for synthesis of 1,3-benzoxazin-4-ones
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9040917/
https://www.ncbi.nlm.nih.gov/pubmed/35480257
http://dx.doi.org/10.1039/d1ra04194k
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