Isostructural cocrystals of metaxalone with improved dissolution characteristics

Muscle relaxant and pain reliever metaxalone (MET) is a biopharmaceutical classification systems (BCS) class II drug with poor aqueous solubility and high permeability. The presence of an aromatic skeleton and cyclic carboxamate moiety are the probable reasons for the decreased aqueous solubility, w...

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Detalles Bibliográficos
Autores principales: Gohel, Sunil Kumar, Palanisamy, Vasanthi, Sanphui, Palash, Prakash, Muthuramalingam, Singh, Girij Pal, Chernyshev, Vladimir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9041148/
https://www.ncbi.nlm.nih.gov/pubmed/35479860
http://dx.doi.org/10.1039/d1ra05959a

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9041148/
https://www.ncbi.nlm.nih.gov/pubmed/35479860
http://dx.doi.org/10.1039/d1ra05959a

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