An efficient synthesis of RNA containing GS-441524: the nucleoside precursor of remdesivir

Remdesivir is an antiviral nucleoside phosphoramidate with activity against multiple viruses, including SARS-CoV-2. To enable studies of viral polymerases with RNA containing remdesivir, we report an efficient synthesis of a phosphoramidite of GS-441524, the nucleoside precursor of remdesivir, and i...

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Detalles Bibliográficos
Autores principales: Moorthy, Ramkumar, Kennelly, Samantha A., Rodriguez, Deborah J., Harki, Daniel A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9041347/
https://www.ncbi.nlm.nih.gov/pubmed/35496844
http://dx.doi.org/10.1039/d1ra06589k

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9041347/
https://www.ncbi.nlm.nih.gov/pubmed/35496844
http://dx.doi.org/10.1039/d1ra06589k

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