An efficient synthesis of RNA containing GS-441524: the nucleoside precursor of remdesivir

Remdesivir is an antiviral nucleoside phosphoramidate with activity against multiple viruses, including SARS-CoV-2. To enable studies of viral polymerases with RNA containing remdesivir, we report an efficient synthesis of a phosphoramidite of GS-441524, the nucleoside precursor of remdesivir, and i...

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Detalles Bibliográficos
Autores principales: Moorthy, Ramkumar, Kennelly, Samantha A., Rodriguez, Deborah J., Harki, Daniel A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9041347/
https://www.ncbi.nlm.nih.gov/pubmed/35496844
http://dx.doi.org/10.1039/d1ra06589k
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author Moorthy, Ramkumar
Kennelly, Samantha A.
Rodriguez, Deborah J.
Harki, Daniel A.
author_facet Moorthy, Ramkumar
Kennelly, Samantha A.
Rodriguez, Deborah J.
Harki, Daniel A.
author_sort Moorthy, Ramkumar
collection PubMed
description Remdesivir is an antiviral nucleoside phosphoramidate with activity against multiple viruses, including SARS-CoV-2. To enable studies of viral polymerases with RNA containing remdesivir, we report an efficient synthesis of a phosphoramidite of GS-441524, the nucleoside precursor of remdesivir, and its incorporation into RNA using automated solid-phase RNA synthesis.
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spelling pubmed-90413472022-04-28 An efficient synthesis of RNA containing GS-441524: the nucleoside precursor of remdesivir Moorthy, Ramkumar Kennelly, Samantha A. Rodriguez, Deborah J. Harki, Daniel A. RSC Adv Chemistry Remdesivir is an antiviral nucleoside phosphoramidate with activity against multiple viruses, including SARS-CoV-2. To enable studies of viral polymerases with RNA containing remdesivir, we report an efficient synthesis of a phosphoramidite of GS-441524, the nucleoside precursor of remdesivir, and its incorporation into RNA using automated solid-phase RNA synthesis. The Royal Society of Chemistry 2021-09-22 /pmc/articles/PMC9041347/ /pubmed/35496844 http://dx.doi.org/10.1039/d1ra06589k Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/
spellingShingle Chemistry
Moorthy, Ramkumar
Kennelly, Samantha A.
Rodriguez, Deborah J.
Harki, Daniel A.
An efficient synthesis of RNA containing GS-441524: the nucleoside precursor of remdesivir
title An efficient synthesis of RNA containing GS-441524: the nucleoside precursor of remdesivir
title_full An efficient synthesis of RNA containing GS-441524: the nucleoside precursor of remdesivir
title_fullStr An efficient synthesis of RNA containing GS-441524: the nucleoside precursor of remdesivir
title_full_unstemmed An efficient synthesis of RNA containing GS-441524: the nucleoside precursor of remdesivir
title_short An efficient synthesis of RNA containing GS-441524: the nucleoside precursor of remdesivir
title_sort efficient synthesis of rna containing gs-441524: the nucleoside precursor of remdesivir
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9041347/
https://www.ncbi.nlm.nih.gov/pubmed/35496844
http://dx.doi.org/10.1039/d1ra06589k
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