Semi-synthetic puwainaphycin/minutissamide cyclic lipopeptides with improved antifungal activity and limited cytotoxicity

Microbial cyclic lipopeptides are an important class of antifungal compounds with applications in pharmacology and biotechnology. However, the cytotoxicity of many cyclic lipopeptides limits their potential as antifungal drugs. Here we present a structure–activity relationship study on the puwainaph...

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Detalles Bibliográficos
Autores principales: Hájek, Jan, Bieringer, Sebastian, Voráčová, Kateřina, Macho, Markéta, Saurav, Kumar, Delawská, Kateřina, Divoká, Petra, Fišer, Radovan, Mikušová, Gabriela, Cheel, José, Fewer, David P., Vu, Dai Long, Paichlová, Jindřiška, Riepl, Herbert, Hrouzek, Pavel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9041360/
https://www.ncbi.nlm.nih.gov/pubmed/35498921
http://dx.doi.org/10.1039/d1ra04882a

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9041360/
https://www.ncbi.nlm.nih.gov/pubmed/35498921
http://dx.doi.org/10.1039/d1ra04882a

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