Use of Physiologically Based Kinetic Modeling-Facilitated Reverse Dosimetry to Predict In Vivo Acute Toxicity of Tetrodotoxin in Rodents

In this study, the ability of a new in vitro/in silico quantitative in vitro–in vivo extrapolation (QIVIVE) methodology was assessed to predict the in vivo neurotoxicity of tetrodotoxin (TTX) in rodents. In vitro concentration–response data of TTX obtained in a multielectrode array assay with primar...

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Detalles Bibliográficos
Autores principales: Noorlander, Annelies, Zhang, Mengying, van Ravenzwaay, Bennard, Rietjens, Ivonne M C M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Emerging Technologies, Methods, and Models
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9041554/
https://www.ncbi.nlm.nih.gov/pubmed/35218365
http://dx.doi.org/10.1093/toxsci/kfac022

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9041554/
https://www.ncbi.nlm.nih.gov/pubmed/35218365
http://dx.doi.org/10.1093/toxsci/kfac022

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