DIBALH: from known fundamental to an unusual reaction; chemoselective partial reduction of tertiary amides in the presence of esters

This study presents a quick and reliable approach to the chemoselective partial reduction of tertiary amides to aldehydes in the presence of readily reducible ester groups using commercial DIBALH reagent. Moreover, the developed method was also extended to multi-functional molecules bearing ester mo...

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Detalles Bibliográficos
Autores principales: Heo, Yu Jin, Kim, Hyun Tae, Jaladi, Ashok Kumar, An, Duk Keun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9042244/
https://www.ncbi.nlm.nih.gov/pubmed/35497556
http://dx.doi.org/10.1039/d1ra06279d
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author Heo, Yu Jin
Kim, Hyun Tae
Jaladi, Ashok Kumar
An, Duk Keun
author_facet Heo, Yu Jin
Kim, Hyun Tae
Jaladi, Ashok Kumar
An, Duk Keun
author_sort Heo, Yu Jin
collection PubMed
description This study presents a quick and reliable approach to the chemoselective partial reduction of tertiary amides to aldehydes in the presence of readily reducible ester groups using commercial DIBALH reagent. Moreover, the developed method was also extended to multi-functional molecules bearing ester moieties, which were successfully chemoselectively reduced to the corresponding aldehydes.
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spelling pubmed-90422442022-04-28 DIBALH: from known fundamental to an unusual reaction; chemoselective partial reduction of tertiary amides in the presence of esters Heo, Yu Jin Kim, Hyun Tae Jaladi, Ashok Kumar An, Duk Keun RSC Adv Chemistry This study presents a quick and reliable approach to the chemoselective partial reduction of tertiary amides to aldehydes in the presence of readily reducible ester groups using commercial DIBALH reagent. Moreover, the developed method was also extended to multi-functional molecules bearing ester moieties, which were successfully chemoselectively reduced to the corresponding aldehydes. The Royal Society of Chemistry 2021-10-18 /pmc/articles/PMC9042244/ /pubmed/35497556 http://dx.doi.org/10.1039/d1ra06279d Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/
spellingShingle Chemistry
Heo, Yu Jin
Kim, Hyun Tae
Jaladi, Ashok Kumar
An, Duk Keun
DIBALH: from known fundamental to an unusual reaction; chemoselective partial reduction of tertiary amides in the presence of esters
title DIBALH: from known fundamental to an unusual reaction; chemoselective partial reduction of tertiary amides in the presence of esters
title_full DIBALH: from known fundamental to an unusual reaction; chemoselective partial reduction of tertiary amides in the presence of esters
title_fullStr DIBALH: from known fundamental to an unusual reaction; chemoselective partial reduction of tertiary amides in the presence of esters
title_full_unstemmed DIBALH: from known fundamental to an unusual reaction; chemoselective partial reduction of tertiary amides in the presence of esters
title_short DIBALH: from known fundamental to an unusual reaction; chemoselective partial reduction of tertiary amides in the presence of esters
title_sort dibalh: from known fundamental to an unusual reaction; chemoselective partial reduction of tertiary amides in the presence of esters
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9042244/
https://www.ncbi.nlm.nih.gov/pubmed/35497556
http://dx.doi.org/10.1039/d1ra06279d
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