Selective targeting of CD38 hydrolase and cyclase activity as an approach to immunostimulation

The ectoenzyme CD38 is highly expressed on the surface of mature immune cells, where they are a marker for cell activation, and also on the surface of multiple tumor cells such as multiple myeloma (MM). CD38-targeted monoclonal antibodies (MABs) such as daratumumab and isatuximab bind to CD38 and pr...

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Detalles Bibliográficos
Autores principales: Benton, Thomas Z., Mills, Catherine M., Turner, Jonathan M., Francis, Megan J., Solomon, Dalan J., Burger, Pieter B., Peterson, Yuri K., Dolloff, Nathan G., Bachmann, André S., Woster, Patrick M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9042253/
https://www.ncbi.nlm.nih.gov/pubmed/35497564
http://dx.doi.org/10.1039/d1ra06266b

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9042253/
https://www.ncbi.nlm.nih.gov/pubmed/35497564
http://dx.doi.org/10.1039/d1ra06266b

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