Dietary stigmastane-type saponins as promising dual-target directed inhibitors of SARS-CoV-2 proteases: a structure-based screening

Despite the development of COVID-19 vaccines, at present, there is still no approved antiviral drug against the pandemic. The SARS-CoV-2 3-chymotrypsin-like proteases (S-3CLpro) and papain-like protease (S-PLpro) are essential for the viral proliferation cycle, hence attractive drug targets. Plant-b...

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Detalles Bibliográficos
Autores principales: Ogunyemi, Oludare M., Gyebi, Gideon A., Ibrahim, Ibrahim M., Olaiya, Charles O., Ocheje, Joshua O., Fabusiwa, Modupe M., Adebayo, Joseph O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9042289/
https://www.ncbi.nlm.nih.gov/pubmed/35497510
http://dx.doi.org/10.1039/d1ra05976a

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9042289/
https://www.ncbi.nlm.nih.gov/pubmed/35497510
http://dx.doi.org/10.1039/d1ra05976a

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