Single amino acid substitutions in hydrophobic cores at a head-coiled coil junction region of cohesin facilitate its release of DNA during anaphase

Cohesin holds sister chromatids together and is cleaved by separase/Cut1 to release DNA during the transition from mitotic metaphase to anaphase. The cohesin complex consists of heterodimeric structural maintenance of chromosomes (SMC) subunits (Psm1 and Psm3), which possess a head and a hinge, sepa...

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Detalles Bibliográficos
Autores principales: Xu, Xingya, Kanai, Ryuta, Wang, Li, Yanagida, Mitsuhiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9042573/
https://www.ncbi.nlm.nih.gov/pubmed/35472286
http://dx.doi.org/10.1098/rsob.210275

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9042573/
https://www.ncbi.nlm.nih.gov/pubmed/35472286
http://dx.doi.org/10.1098/rsob.210275

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