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Tea consumption and risk of incident dementia: A prospective cohort study of 377 592 UK Biobank participants

As a widely consumed beverage, tea boasts diverse health benefits. Herein, we aimed to investigate the association between tea consumption and dementia risk. We conducted a prospective cohort study with 377 592 UK Biobank participants during a 9-year follow-up. Cox regression models adjusted for age...

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Autores principales: Hu, He-Ying, Wu, Bang-Sheng, Ou, Ya-Nan, Ma, Ya-Hui, Huang, Yu-Yuan, Cheng, Wei, Tan, Lan, Yu, Jin-Tai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9042826/
https://www.ncbi.nlm.nih.gov/pubmed/35474192
http://dx.doi.org/10.1038/s41398-022-01923-z
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author Hu, He-Ying
Wu, Bang-Sheng
Ou, Ya-Nan
Ma, Ya-Hui
Huang, Yu-Yuan
Cheng, Wei
Tan, Lan
Yu, Jin-Tai
author_facet Hu, He-Ying
Wu, Bang-Sheng
Ou, Ya-Nan
Ma, Ya-Hui
Huang, Yu-Yuan
Cheng, Wei
Tan, Lan
Yu, Jin-Tai
author_sort Hu, He-Ying
collection PubMed
description As a widely consumed beverage, tea boasts diverse health benefits. Herein, we aimed to investigate the association between tea consumption and dementia risk. We conducted a prospective cohort study with 377 592 UK Biobank participants during a 9-year follow-up. Cox regression models adjusted for age, sex, ethnicity, Townsend deprivation index, education, body mass index, lifestyle factors, dietary factors and apolipoprotein E4 status were used to examine the association of tea consumption with dementia risk. Subgroup analyses stratified by age, sex and forms of dementia (Alzheimer’s disease [AD] and vascular dementia [VD]) were performed. Moreover, the restricted cubic splines were used to calculate the nonlinear relationship between daily dosage of tea and dementia risk. After adjustment for all covariates, tea drinkers were 16% (95% confidence interval: 8–23) less likely to develop dementia compared with non-drinkers. Moderate consumption (1–6 cups/day) of tea exerted significant protective effects. Subgroup analyses showed that mid-aged participants or males benefited more from tea consumption. Moreover, moderate drinkers had a 16–19% lower hazard of AD and a 25–29% lower hazard of VD. Furthermore, a U-shaped association between tea consumption and dementia risk was shown (P(non-linearity) = 7E(−04)), and the consumption of around three cups per day showed the strongest protective effect. Within 3 cups/day, drinking one extra cup of tea per day brought a 6% reduction of incidence. In conclusion, moderate consumption of tea was significantly associated with a reduced risk of dementia, suggesting that tea consumption could be a modifiable lifestyle factor for dementia.
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spelling pubmed-90428262022-04-28 Tea consumption and risk of incident dementia: A prospective cohort study of 377 592 UK Biobank participants Hu, He-Ying Wu, Bang-Sheng Ou, Ya-Nan Ma, Ya-Hui Huang, Yu-Yuan Cheng, Wei Tan, Lan Yu, Jin-Tai Transl Psychiatry Article As a widely consumed beverage, tea boasts diverse health benefits. Herein, we aimed to investigate the association between tea consumption and dementia risk. We conducted a prospective cohort study with 377 592 UK Biobank participants during a 9-year follow-up. Cox regression models adjusted for age, sex, ethnicity, Townsend deprivation index, education, body mass index, lifestyle factors, dietary factors and apolipoprotein E4 status were used to examine the association of tea consumption with dementia risk. Subgroup analyses stratified by age, sex and forms of dementia (Alzheimer’s disease [AD] and vascular dementia [VD]) were performed. Moreover, the restricted cubic splines were used to calculate the nonlinear relationship between daily dosage of tea and dementia risk. After adjustment for all covariates, tea drinkers were 16% (95% confidence interval: 8–23) less likely to develop dementia compared with non-drinkers. Moderate consumption (1–6 cups/day) of tea exerted significant protective effects. Subgroup analyses showed that mid-aged participants or males benefited more from tea consumption. Moreover, moderate drinkers had a 16–19% lower hazard of AD and a 25–29% lower hazard of VD. Furthermore, a U-shaped association between tea consumption and dementia risk was shown (P(non-linearity) = 7E(−04)), and the consumption of around three cups per day showed the strongest protective effect. Within 3 cups/day, drinking one extra cup of tea per day brought a 6% reduction of incidence. In conclusion, moderate consumption of tea was significantly associated with a reduced risk of dementia, suggesting that tea consumption could be a modifiable lifestyle factor for dementia. Nature Publishing Group UK 2022-04-26 /pmc/articles/PMC9042826/ /pubmed/35474192 http://dx.doi.org/10.1038/s41398-022-01923-z Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Hu, He-Ying
Wu, Bang-Sheng
Ou, Ya-Nan
Ma, Ya-Hui
Huang, Yu-Yuan
Cheng, Wei
Tan, Lan
Yu, Jin-Tai
Tea consumption and risk of incident dementia: A prospective cohort study of 377 592 UK Biobank participants
title Tea consumption and risk of incident dementia: A prospective cohort study of 377 592 UK Biobank participants
title_full Tea consumption and risk of incident dementia: A prospective cohort study of 377 592 UK Biobank participants
title_fullStr Tea consumption and risk of incident dementia: A prospective cohort study of 377 592 UK Biobank participants
title_full_unstemmed Tea consumption and risk of incident dementia: A prospective cohort study of 377 592 UK Biobank participants
title_short Tea consumption and risk of incident dementia: A prospective cohort study of 377 592 UK Biobank participants
title_sort tea consumption and risk of incident dementia: a prospective cohort study of 377 592 uk biobank participants
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9042826/
https://www.ncbi.nlm.nih.gov/pubmed/35474192
http://dx.doi.org/10.1038/s41398-022-01923-z
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