Blockade of inhibitory killer cell immunoglobulin-like receptors and IL-2 triggering reverses the functional hypoactivity of tumor-derived NK-cells in glioblastomas

Killer cell immunoglobulin-like receptors (KIRs) comprise a group of highly polymorphic inhibitory receptors which are specific for classical HLA class-I molecules. Peripheral blood and freshly prepared tumor cell suspensions (n = 60) as well as control samples (n = 32) were investigated for the dis...

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Detalles Bibliográficos
Autores principales: Sönmez, Cüneyt, Wölfer, Johannes, Holling, Markus, Brokinkel, Benjamin, Stummer, Walter, Wiendl, Heinz, Thomas, Christian, Schulte-Mecklenbeck, Andreas, Grauer, Oliver M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9042843/
https://www.ncbi.nlm.nih.gov/pubmed/35474089
http://dx.doi.org/10.1038/s41598-022-10680-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9042843/
https://www.ncbi.nlm.nih.gov/pubmed/35474089
http://dx.doi.org/10.1038/s41598-022-10680-4

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