Knockdown of GABA(A) alpha3 subunits on thalamic reticular neurons enhances deep sleep in mice

Identification of mechanisms which increase deep sleep could lead to novel treatments which promote the restorative effects of sleep. Here, we show that knockdown of the α3 GABA(A)-receptor subunit from parvalbumin neurons in the thalamic reticular nucleus using CRISPR-Cas9 gene editing increased th...

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Detalles Bibliográficos
Autores principales: Uygun, David S., Yang, Chun, Tilli, Elena R., Katsuki, Fumi, Hodges, Erik L., McKenna, James T., McNally, James M., Brown, Ritchie E., Basheer, Radhika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9042958/
https://www.ncbi.nlm.nih.gov/pubmed/35473906
http://dx.doi.org/10.1038/s41467-022-29852-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9042958/
https://www.ncbi.nlm.nih.gov/pubmed/35473906
http://dx.doi.org/10.1038/s41467-022-29852-x

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