Chemical synthesis of the organoarsenical antibiotic arsinothricin

We report two routes of chemical synthesis of arsinothricin (AST), the novel organoarsenical antibiotic. One is by condensation of the 2-chloroethyl(methyl)arsinic acid with acetamidomalonate, and the second involves reduction of the N-acetyl protected derivative of hydroxyarsinothricin (AST-OH) and...

Descripción completa

Detalles Bibliográficos
Autores principales: Howlader, A. Hasan, Suzol, Sazzad H., Nadar, Venkadesh Sarkarai, Galván, Adriana Emilce, Nedovic, Aleksandra, Cudic, Predrag, Rosen, Barry P., Yoshinaga, Masafumi, Wnuk, Stanislaw F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9043123/
https://www.ncbi.nlm.nih.gov/pubmed/35493177
http://dx.doi.org/10.1039/d1ra06770b

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9043123/
https://www.ncbi.nlm.nih.gov/pubmed/35493177
http://dx.doi.org/10.1039/d1ra06770b

Ejemplares similares