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Chemical synthesis of the organoarsenical antibiotic arsinothricin

We report two routes of chemical synthesis of arsinothricin (AST), the novel organoarsenical antibiotic. One is by condensation of the 2-chloroethyl(methyl)arsinic acid with acetamidomalonate, and the second involves reduction of the N-acetyl protected derivative of hydroxyarsinothricin (AST-OH) and...

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Detalles Bibliográficos
Autores principales:	Howlader, A. Hasan, Suzol, Sazzad H., Nadar, Venkadesh Sarkarai, Galván, Adriana Emilce, Nedovic, Aleksandra, Cudic, Predrag, Rosen, Barry P., Yoshinaga, Masafumi, Wnuk, Stanislaw F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society of Chemistry 2021
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9043123/ https://www.ncbi.nlm.nih.gov/pubmed/35493177 http://dx.doi.org/10.1039/d1ra06770b

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