Mechanisms of enhanced aggregation and fibril formation of Parkinson’s disease-related variants of α-synuclein

Aggregation of α-synuclein (α-syn) into amyloid fibrils is closely associated with Parkinson’s disease (PD). Familial mutations or posttranslational truncations in α-syn are known as risk factor for PD. Here, we examined the effects of the PD-related A30P or A53T point mutation and C-terminal 123–14...

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Detalles Bibliográficos
Autores principales: Ohgita, Takashi, Namba, Norihiro, Kono, Hiroki, Shimanouchi, Toshinori, Saito, Hiroyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9043213/
https://www.ncbi.nlm.nih.gov/pubmed/35474118
http://dx.doi.org/10.1038/s41598-022-10789-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9043213/
https://www.ncbi.nlm.nih.gov/pubmed/35474118
http://dx.doi.org/10.1038/s41598-022-10789-6

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